When an upgrade is performed there should be a mechanism for informing the user(s) about manual actions that should be performed.
An API should be provided to cause a message to be displayed on all screens that a user visits, together with a button to remove the message. The message should be either "global" or "individual". If global, then the first user to click the "acknowledge" will close the message for all users. If the message is not "global" then each user of the system will have to signal acknowledgment of the notice.